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  • Title: Minireview: trichosanthin--a protein with multiple pharmacological properties.
    Author: Shaw PC, Chan WL, Yeung HW, Ng TB.
    Journal: Life Sci; 1994; 55(4):253-62. PubMed ID: 8028444.
    Abstract:
    Trichosanthin (TCS), a protein isolated from the root tuber of the Chinese medicinal herb Trichosanthes kirilowii Maxim., is used to induce abortion in China. It also possesses immunomodulatory, anti-tumor and anti-human immunodeficiency virus properties. TCS is a member of the family of ribosome-inactivating proteins and inactivates eukaryotic ribosomes via its N-glycosidase activity. The gene encoding TCS has been cloned and over-expressed and the crystal structure of this protein resolved to 1.73A. In this review, the various pharmacological properties of TCS are discussed and assessed.
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