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  • Title: Inhibitory effect of the alpha 1-adrenergic antagonist prazosin on food intake in pygmy goats.
    Author: Rossi R, Scharrer E.
    Journal: Pharmacol Biochem Behav; 1994 Apr; 47(4):851-6. PubMed ID: 8029255.
    Abstract:
    The effect of the intraperitoneally (IP) injected alpha 1-adrenergic antagonist prazosin (15, 40, 130 and 537 micrograms/kg b.wt.) on feed intake and plasma free fatty acid (FFA) levels was studied in 12 adult female African pygmy goats. Prazosin produced a dose-dependent long-lasting hypophagia and a dose-dependent increase in plasma FFA levels. The hypophagic effect of prazosin and the elevation in plasma FFA induced by prazosin were abolished by concomitant injection of the beta-adrenergic antagonist propranolol (500 micrograms/kg b.wt.). The hypophagic effect of prazosin (40 micrograms/kg) was also abolished by concomitant injection of the hypertonic agent angiotensin II (AII: 1 microgram/kg). The results suggest that blockade of alpha 1-adrenergic receptors by prazosin-producing hypotension elicits a counterregulatory sympathetic activation, which reduces voluntary food intake by activation of beta-adrenergic receptors. The dose dependence of the inhibition of food intake and of the elevation of plasma FFA after prazosin suggests that the hypophagia due to prazosin may be partly a consequence of elevated plasma FFA.
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