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  • Title: Effects of Chinese herbal medicines on DNA-synthesizing enzyme activities in mammary tumors of mice.
    Author: Sakamoto S, Furuichi R, Matsuda M, Kudo H, Suzuki S, Sugiura Y, Kuwa K, Tajima M, Matsubara M, Namiki H.
    Journal: Am J Chin Med; 1994; 22(1):43-50. PubMed ID: 8030618.
    Abstract:
    Sho-saiko-to (SST) and Juzen-taiho-to (JTT), Japanese modified Chinese herbal prescriptions, suppressed the activities of thymidylate synthetase and thymidine kinase involved in de novo and salvage pathways for pyrimidine nucleotide synthesis, respectively, in mammary tumors of SHN mice with the reduction of serum prolactin level. These results indicate that SST and JTT may have the antitumor effects on mammary tumors.
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