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  • Title: Toxic effect of puromycin on erythrocyte membranes which is unrelated to inhibition of protein synthesis.
    Author: Burka ER, Ballas SK, Sabesin SM.
    Journal: Blood; 1975 Jan; 45(1):21-7. PubMed ID: 803107.
    Abstract:
    Exposure of rabbit or human erythrocytes to concentrations of puromycin as low as 7 x 10(-4)M for 2 hr causes damage to the cell membrane, as evidenced by increased susceptibility of the cells to hyposmotic lysis, increased cell rigidity, and ultrastructural changes consistent with severe membrane damage. Puromycin causes a concentration-dependent internalization of the erythrocyte membrane, resulting in vacuolization of the cells, at concentrations between 7 x 10(-4) M and 10(-2) M. Since the erythrocyte does not synthesize protein, the data indicate that puromycin has a direct toxic effect on erythroid cell membranes which is unrelated to its action in inhibiting the synthesis of protein.
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