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  • Title: [Thiamine deficiency associated with parenteral nutrition: apropos of a new case].
    Author: Sanz París A, Albero Gamoa R, Acha Pérez FJ, Playán Usón J, Casamayor Peris L, Celaya Pérez S.
    Journal: Nutr Hosp; 1994; 9(2):110-3. PubMed ID: 8031948.
    Abstract:
    In thiamine deficiency, the Krebs cycle slows large quantities of pyruvate are diverted to lactate production and anaerobic metabolism begins. The most frequent cause of this syndrome is a dietary deficiency associated to a greater or lesser degree with alcoholism. Other less frequent causes are the ingestion of raw fish contaminated with microbial thiaminases, inborn errors of metabolism and total parenteral nutrition. We present the clinical case of a patient with an acute thiamine deficiency after 15 days of total parenteral nutrition, which improved with intravenous administration of thiamine. The incidence of beriberi among patients undergoing total parenteral nutrition is very low because of the almost systematic addition of vitamin complexes. Our patient's clinical picture was sudden, corresponding to the dry form, with typical neurological symptoms and signs, major metabolic acidosis, hyperglycemia and hyponatremia. The clinical response to the administration of thiamine confirmed the diagnosis.
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