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  • Title: Distribution of prostaglandin E 9-KETOREDUCTASE AND TYPES I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex.
    Author: Lee SC, Pong SS, Katzen D, Wu KY, Levine L.
    Journal: Biochemistry; 1975 Jan 14; 14(1):142-5. PubMed ID: 803247.
    Abstract:
    Prostaglandin E 9-ketoreductase, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I), and NADP+-dependent 15-hydroxyprostaglandin dehydrogenase (type II) have been partially purified from swine renal medulla and cortex. Eleven times more NAD+-dependent 15-hydroxyprostaglandin dehydrogenase activity was found in the cortex than in the medulla. On the other hand, about twice as much NADP+-dependent dehydrogenase activity was found in the medulla than in the cortex. The prostaglandin 9-ketoreductase activities were equally distributed in the swine kidney cortex and medulla.
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