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  • Title: [The morphoimmunological correlates in the leukemic degeneration of prolymphocytic lymphosarcoma].
    Author: Frenkel' MA, Sokirka TE, Lebedeva NB, Tupitsyn NN, Baryshnikov AIu, Solov'eva EA.
    Journal: Klin Lab Diagn; 1993; (6):32-7. PubMed ID: 8032777.
    Abstract:
    Morphocytochemical and immunologic features of the bone marrow and peripheral blood lymphoid elements were studied in 40 patients with B-prolymphocytic lymphosarcoma in the stage of leukemic degeneration. Four types of pathologic lymphoid cells were distinguished: large prolymphocytes expressing pan-B CD19 and HLA-Dr antigens, medium-sized prolymphocytes with round nuclei, characterized by activation CD38 and CD45Ra antigens, prolymphocytes with split nuclei containing light and heavy immunoglobulin chains, and leukemic lymphocytes containing, besides pan-B antigens and immunoglobulins, antigens of the early hemopoietic (CD34) and early B-(CD10) precursors. The content of the RAS-positive substance in the prolymphocytes was inversely proportional to the parameters of activation antigens expression. Acid phosphatase activity correlated with the expression of CD22 and CD45Ra antigens.
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