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  • Title: Negative ANCA in Wegener's granulomatosis.
    Author: Carrie S, Hughes KB, Watson MG.
    Journal: J Laryngol Otol; 1994 May; 108(5):420-2. PubMed ID: 8035124.
    Abstract:
    Wegener's granulomatosis is a systemic vasculitis characterized by necrotizing granulomata and without treatment is associated with a poor prognosis. Antineutrophil cytoplasmic antibodies (ANCA) have proved to be a useful serological marker allowing for early diagnosis and treatment of this condition. We report two cases of patients who were ANCA-negative on presentation despite clinical suspicion of Wegener's granulomatosis. In both cases the patients developed a positive ANCA titre as the disease progressed.
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