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  • Title: Genomic organization of the translocations (8;14) and (14;18) in a new lymphoma cell line.
    Author: Lambrechts AC, Dorssers LC, Hupkes PE, van Gurp R, Baumgarten R, Hagemeijer A, van 't Veer MB, Touw IP.
    Journal: Leukemia; 1994 Jul; 8(7):1164-71. PubMed ID: 8035608.
    Abstract:
    We generated a new lymphoma cell line carrying the translocations (8;14) and (14;18) and studied the genomic organization and expression of the BCL-2 and MYC genes. Polymerase chain reaction (PCR) and Southern analysis showed that the breakpoints of t(14;18) were located in the major breakpoint region (mbr) of the BCL-2 gene and just 5' of JH6 in the IgH locus. The breakpoints of the t(8;14) were located upstream of exon 2 in the non-coding region of the MYC gene and near the switch region of the IgH locus. Both IgH loci were involved in chromosomal translocations resulting in the absence of a functional B-cell receptor. Normal BCL-2 and truncated MYC transcripts were detected in these cells. The BCL-2 protein was expressed.
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