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  • Title: [The concept of stress and the role of hypothalamic and extra-hypothalamic corticotropin-releasing factor (CRF) in the integration of the neuroendocrine and immune responses. Clinical and experimental aspects].
    Author: Puri PL, Palma A, Fabbri A.
    Journal: Minerva Endocrinol; 1994 Mar; 19(1):19-28. PubMed ID: 8035767.
    Abstract:
    Several evidences suggest the existence of a bidirectional link between the immune and neuroendocrine systems. This relationship explains how a "non cognitive" stimulus (as antigen) can activate the neuroendocrine axis through the inflammatory substances (cytokines) in the same manner as a stress response. A disregulation of this response can determine the basis for a pathological situation. The key-peptide of the stress response is hypothalamic CRF, though also extra-hypothalamic sources, such as the cells of the immune system, are present and could play an important role in the peripheral regulation of stress response.
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