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  • Title: Transplantation of a hepatitis B surface antigen-positive donor liver into a hepatitis B virus-negative recipient.
    Author: González-Peralta RP, Andres JM, Tung FY, Fang JW, Brunson ME, Davis GL, Lau JY.
    Journal: Transplantation; 1994 Jul 15; 58(1):114-6. PubMed ID: 8036699.
    Abstract:
    A critically ill, HBV seronegative girl who received a liver from a HBsAg+ donor is described. Despite HBV Ig prophylaxis, she was seropositive for HBsAg shortly after transplantation. Although the postoperative period was complicated, HBV-related problems were not encountered. Liver dysfunction was noted 7 months after transplantation. At that time, she became anti-HBc IgM-positive, with liver histologic findings suggestive of chronic active hepatitis B. The liver function normalized after a reduction of immunosuppressive therapy and introduction of ciprofloxacin. The patient had low level HBV replication during the entire follow-up period (HBV DNA-positive by PCR only) and sequencing of the virus on 4 occasions revealed only wild-type HBV. She subsequently lost serum HBsAg and HBV DNA (even by PCR) and has remained well 2 years after transplantation.
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