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  • Title: [The dependence of the function of the sympathetic-adrenal and hypothalamo-hypophyseal-adrenal cortical systems on the severity of the traumatic brain lesion].
    Author: Kaasik AE, Kyĭv LE, Paiu AA, Tomberg TA, Merisalu EP, Tsil'mer KIa.
    Journal: Zh Vopr Neirokhir Im N N Burdenko; 1994; (1):26-9. PubMed ID: 8036856.
    Abstract:
    A total of 43 males with craniocerebral injury of varying severity were studied for the venous blood plasma levels of adrenaline, noradrenaline, adrenocorticotrophic hormone, and hydrocortisone in dynamics. Their computed tomograms were quantitatively analysed to identify the site of contusion foci in the cerebral hemispheres, especially the lesion signs of mesodiencephalic and truncal regions of the brain. The results of the studies and non-linear regression analysis have shown that brain injury leads to a substantial activation of the body's sympathoadrenal system, extremely severe injury causes its partial reduced performance. In severe and critical cerebrocranial injury, the central link of the hypothalamus-pituitary-adrenocortical system is exhausted and hydrocortisone release occurs without its control. The above changes depend on the size of hepatoma and edema of the cerebral hemispheres and on secondary lesion of the brain mesodiencephalic and truncal regions. The activity of the sympathoadrenal and hypothalamus-pituitary-adrenocortical system, which was observed over a week, tended to its gradual decrease.
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