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  • Title: [Studies on semi-synthesis of cephalotaxine esters and correlation of their structures with antitumor activity].
    Author: Zhong SB, Liu WC, Li RL, Ling YZ, Li CH, Tu GZ, Ma LB, Hong SL.
    Journal: Yao Xue Xue Bao; 1994; 29(1):33-8. PubMed ID: 8036899.
    Abstract:
    Ten esters of cephalotaxine with amino acids possessing widely different structural features have been synthesized and tested for antitumor activity. Preliminary data showed that compound 6 is the most active one. However, it is still less potent than harringtonine. Other synthetic esters possess varying activities at 10 micrograms/ml. Preliminary structure activity relationship of these esters was discussed.
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