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  • Title: [Carcinosarcoma arising in eccrine spiradenoma. A morphologic and immunohistochemical study].
    Author: Huerre M, Bonnet D, Mc Carthy SW, de Saint Maur PP.
    Journal: Ann Pathol; 1994; 14(3):168-73. PubMed ID: 8037805.
    Abstract:
    Malignant change in a benign eccrine spiradenoma is a rare but definite phenomenon. Since it was first reported by Dabska, 23 cases have been reported. All cases present recent changes in a long standing cutaneous nodule which, when excised and examined microscopically, disclosed carcinoma associated and arising from benign eccrine spiradenoma. Eight patients died of disseminated tumours. Histologic features, in three fatal cases, showed carcinosarcoma and particularly osteosarcoma in one case. A further fatal case of carcinosarcoma arising in spiradenoma, is reported in a Melanesian man aged 38, who died after 8 months. Histologic examination showed squamous cell carcinoma associated with osteosarcoma in the recurrence.
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