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  • Title: Effect of dopamine on carotid chemoreceptor activity in newborn kittens.
    Author: Bairam A, Hannhart B, Choné C, Marchal F.
    Journal: Biol Neonate; 1994; 65(3-4):140-4. PubMed ID: 8038274.
    Abstract:
    In newborn kittens, intravenous bolus injections of dopamine may be inhibitory or excitatory to the carotid chemosensory activity. In order to further identify the role of dopaminergic mechanisms on the chemosensory activity in the kitten, 10 anesthetized, paralyzed and artificially ventilated kittens aged from 1 to 21 days were studied. The activity of a few chemoafferent fibers from one carotid sinus nerve was recorded at three levels of FiO2 in N2, 21, 8 and 100%, before and during a continuous dopamine infusion at a dose of 10 micrograms/kg/min. The immediate effect of dopamine usually was a transient inhibition of carotid chemosensory discharge. After 2 min of infusion, the activity had consistently increased from 4.5 +/- 0.8 to 8.8 +/- 1.4 impulses/s (mean +/- SEM, p < 0.05) in normoxia. Dopamine also significantly increased the steady state chemosensory response to hypoxia from 24.6 +/- 3.7 to 33.4 +/- 5.3 impulses/s. Hence, continuous infusion of dopamine has a dual effect on carotid chemoreceptor activity: early inhibition followed by excitation. The excitatory effect enhances the response to hypoxia. These data suggest that the dual effect of dopamine on carotid chemosensory discharge may be related to dopamine concentration in the carotid body.
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