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  • Title: The importance of interferon-gamma in an early infection of Chlamydia psittaci in mice.
    Author: McCafferty MC, Maley SW, Entrican G, Buxton D.
    Journal: Immunology; 1994 Apr; 81(4):631-6. PubMed ID: 8039814.
    Abstract:
    Athymic mice (nu/nu) and their hairy littermates (nu/+) were infected experimentally with Chlamydia psittaci and the role of endogenous interferon-gamma (IFN-gamma) on the resolution of the infection was studied. The pathological changes produced in the spleen, liver and lung were exacerbated by administration of a monoclonal antibody (mAb) to IFN-gamma and an increased number of viable chlamydiae were recovered from the tissues of both nu/+ and nu/nu mice treated in this way.
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