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  • Title: [Guanfu base A inhibit the post-infarction ventricular arrhythmias in dogs].
    Author: Wang YQ, Su L, Gong GQ, Liu JH.
    Journal: Yao Xue Xue Bao; 1994; 29(2):141-4. PubMed ID: 8042512.
    Abstract:
    Harris tow-stage left anterior coronary ligation was performed in anesthetized dogs. After twenty hours, severe ventricular arrhythmias were recorded under conscious state. Cumulative intravenous injections of guanfu base A, a new alkaloid isolated from the tuber of Aconitum coreanum in China, from 10 to 40 mg.kg-1 produced remarkable antiarrhythmic effect lasting over 30 min and a moderate reduction of heart rate. The P-R interval, QRS complex and Q-T interval of the sinus rhythm were not significantly altered. The antiarrhythmic potency of guanfu base A in this model was found to be about one third that of quinidine.
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