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  • Title: Case report: treatment of an intracranial arteriovenous malformation in a patient with complicated hemophilia.
    Author: Andrews BT, Stricker RB, Kitt D, Galanakis DK, Gerson LB, Hieshima GB.
    Journal: Am J Med Sci; 1994 Aug; 308(2):106-9. PubMed ID: 8042649.
    Abstract:
    The authors describe a young man with hemophilia complicated by chronic hepatic dysfunction, hypodysfibrinogenemia, and immune thrombocytopenia that resulted in a complex coagulopathy. The patient had a ruptured occipital arteriovenous malformation. The malformation was managed by temporary correction of the coagulopathy using cryoprecipitate, platelet transfusions, and plasmapheresis with fresh frozen plasma replacement. The patient underwent staged preoperative embolization followed by surgical excision of the lesion. Hemostasis was acceptable during the neurointerventional and subsequent surgical management, and no complications of coagulopathy occurred. Plasmapheresis may provide effective preparation for patients with hemophilia and complex coagulation abnormalities who require neurosurgical intervention.
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