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  • Title: 1,2,3-Triazole[4,5-d]pyridazines--II. New derivatives tested on adenosine receptors.
    Author: Biagi G, Giorgi I, Livi O, Scartoni V, Martini C, Tacchi P, Merlino S, Pasero M.
    Journal: Farmaco; 1994 Mar; 49(3):175-81. PubMed ID: 8043168.
    Abstract:
    This paper reports the synthesis and biological evaluation towards A1 and A2 adenosine receptors of new 1,2,3-triazole[4,5-d]pyridazines bearing lipophilic substituents in the 1 position. Some 1-benzyl-4-substituted amino derivatives were prepared and the cyclohexylamino-, anilino- and p-toluidino- derivatives showed an interesting moderately selective activity on the A1 receptor.
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