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  • Title: alpha-Interferon in myelofibrosis: a case report.
    Author: Dalla KP, Zeigler ZR, Shadduck RK.
    Journal: Br J Haematol; 1994 Mar; 86(3):654-6. PubMed ID: 8043450.
    Abstract:
    A patient with advanced myeloid metaplasia was treated with alpha-interferon (29 months) with a remarkable response. He had anaemia, thrombocytopenia and hepatosplenomegaly with infarction. The initial bone marrow showed replacement with fibrosis with no evident haemopoietic cells. Post-therapy, the patient became asymptomatic, transfusion independent and had normal blood counts. The repeat bone marrow was 30% cellular with 1 + reticulin and no fibrosis. Treatment was well tolerated without appreciable side-effects. These results indicate that prolonged therapy with alpha-interferon can improve haemopoiesis and reverse marrow fibrosis.
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