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  • Title: [Pulmonary hemodynamics and hemostasis in rabbits exposed to high altitude].
    Author: Almerekova AA, Tartakovskiĭ VN, Isakova ZhT.
    Journal: Aviakosm Ekolog Med; 1993; 27(3):28-33. PubMed ID: 8044148.
    Abstract:
    Pulmonary hemodynamics, homeostasis and red blood parameters were studied in 77 rabbits in the mountains of the Tien Shan (3200 m above sea-level). Exposure of animals in alpine environment gave rise to pulmonary hypertension, polycythemia, alterations of homeostasis by the pattern of hyper- and hypocoagulation syndrome. On certain stages of adaptation products of paracoagulation were observed in blood as well as intravascular aggregation of formed elements, increased sensitivity of blood plates to platelet activation, increased fibrinolysis. Given existing hypothesis about involvement of changes in homeostasis and red blood in the pathogenesis of altitude pulmonary hypertension, the coefficients of paired linear correlation between indices of pulmonary hemodynamics and blood have been calculated. These coefficients are valid only for low values of the ratio.
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