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  • Title: Interpersonal variables in the prediction of alcoholism among adoptees: evidence for gene-environment interactions.
    Author: Cutrona CE, Cadoret RJ, Suhr JA, Richards CC, Troughton E, Schutte K, Woodworth G.
    Journal: Compr Psychiatry; 1994; 35(3):171-9. PubMed ID: 8045106.
    Abstract:
    The contributions of genetic and both positive and negative environmental factors were tested in the prediction of alcohol abuse/dependence among 300 adult adoptees. No direct effects for either genetic or environmental factors were significant in the prediction of adoptee alcohol abuse/dependence. However, among women, early-life family conflict and psychopathology in the adoptive family interacted with a biological background of alcoholism. Among women with at least one alcoholic biological parent, conflict or psychopathology in the adoptive family increased the probability of alcohol abuse and/or dependence. Among men, no significant interactions were found between a biological background of alcoholism and environmental variables. Results suggest a pattern of gene-environment interaction among women.
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