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  • Title: The induction of delayed hypersensitivity in guinea pigs to poly U and poly A:U.
    Author: Casavant CH, Youmans GP.
    Journal: J Immunol; 1975 May; 114(5):1506-9. PubMed ID: 804517.
    Abstract:
    Guinea pigs were sensitized to poly U and poly A:U so that subsequent stimulation of spleen cells from these immunized animals with poly U and poly A:U resulted in the production of migration inhibitory factor (MIF). MIF was also produced when spleen cells from animals immunized with poly A:U were cultured in the presence of mycobacterial RNA or whole viable H37 Ra cells. Negative dermal reactions were observed when guinea pigs immunized with poly A, poly A:U were skin tested wtih these same synthetic nucleotides.
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