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  • Title: Mechanism of activation of the TGF-beta receptor.
    Author: Wrana JL, Attisano L, Wieser R, Ventura F, Massagué J.
    Journal: Nature; 1994 Aug 04; 370(6488):341-7. PubMed ID: 8047140.
    Abstract:
    Transforming growth factor-beta (TGF-beta) signals by contacting two distantly related transmembrane serine/threonine kinases called receptors I and II. The role of these molecules in signalling has now been determined. TGF-beta binds directly to receptor II, which is a constitutively active kinase. Bound TGF-beta is then recognized by receptor I which is recruited into the complex and becomes phosphorylated by receptor II. Phosphorylation allows receptor I to propagate the signal to downstream substrates. This provides a mechanism by which a cytokine can generate the first step of a signalling cascade.
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