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  • Title: Neuroprotective effects of colchicine in the gerbil model of cerebral ischaemia.
    Author: Pratt J, Roux M, Henneguelle E, Stutzmann JM, Laduron PM.
    Journal: Neurosci Lett; 1994 Mar 14; 169(1-2):114-8. PubMed ID: 8047263.
    Abstract:
    The tropolonic alkaloid colchicine significantly reduces the behavioural, electroencephalographic and histological damage seen after a 6-min occlusion of the two common carotid arteries of the Mongolian gerbil if the compound is administered at 2 or 4 mg/kg i.p. immediately upon reperfusion. A 45% increase in high-frequency ECoG activity and significant reduction of 80% in the hypermotility of the gerbils, with 63% less faults in a passive avoidance paradigm, were observed in conjunction with considerable protection of the hippocampus, after a single dose of 4 mg/kg colchicine. No adverse effects of colchicine treatment on animal movement and body weight were observable. Colchicine's possible mode of action, via inhibition of cellular transport systems, is discussed.
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