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  • Title: [The use of taktivin in experimental apical periodontitis exacerbated by a secondary immunodeficiency state].
    Author: Zyrianov GV, Dmitrieva LA, Frolova TM, Belopol'skiĭ AA, Babaian SS.
    Journal: Stomatologiia (Mosk); 1993; 72(2):10-3. PubMed ID: 8048117.
    Abstract:
    Apical periodontitis was simulated in 100 white rats with secondary immunodeficiency induced by a single total x-ray irradiation with the RUM [correction of PYM]-17 device. Nonspecific resistance of the rat body was assessed from the neutrophilic phagocytic activity, serum bactericidal activity, lysozyme and complement levels. These parameters were found reduced in the experimental animals; x-ray examinations revealed changes round the dental root apices. Daily injections of tactivin for 10 days in a dose 2-5 mg/kg b.m. resulted in elevation of the nonspecific resistance parameters, and the x-ray picture in this group of animals was the same as in intact controls; therefore, tactivin normalized the immunity system status and indirectly improved the clinical course of apical periodontitis.
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