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  • Title: O-(2-dialkylaminoethyl)oximes of 5-(arylmethylene)-1,3,3-trimethyl-2-oxabicyclo [2.2.2]octan-6-ones with hypotensive, antiarrhythmic and other activities.
    Author: Mariani E, Bargagna A, Longobardi M, Schenone P, D'Amico M, Filippelli W, Falciani M, Filippelli A.
    Journal: Farmaco; 1994 Apr; 49(4):267-70. PubMed ID: 8049006.
    Abstract:
    The synthesis of some O-(2-dialkylaminoethyl)oximes of 5-[(4-methoxy- or 4-methylthiophenyl)methylene]-1,3,3-trimethyl-2-oxabicyclo[2.2.2] octan-6-ones 5 by reaction of the corresponding oximes as sodium salts with the appropriate 2-chloroethyldialkylamine in dry ethanol solution is described. Some aminoethers 5 showed appreciable hypotensive and antiarrhythmic activities in rats, as well as a weak platelet antiaggregating activity in vitro and a moderate infiltration anesthesia in mice.
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