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Title: Cytotoxic activity of some gold(III) complexes. Author: Cossu F, Matovic Z, Radanovic D, Ponticelli G. Journal: Farmaco; 1994 Apr; 49(4):301-2. PubMed ID: 8049012. Abstract: The [Au(N-MeIm)Cl3], [Au(2-MeBO)Cl3] and [Au(2,5-diMeBO)Cl3] complexes (where N-MeIm = N-methylimidazole, 2-MeBO = 2-methylbenzoxazole and 2,5-diMeBO = 2,5-dimethylbenzoxazole), had been previously prepared and characterized by the Author. These compounds, when tested in vitro against murine leukemia cell lines L1210, human ovarian carcinoma A2780 and their sublines L1210/CDDP and A2780/CDDP resistant to cisplatin, in comparison with cisplatin and carboplatin, showed an interesting cytotoxicity, extended to resistant sublines.[Abstract] [Full Text] [Related] [New Search]