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  • Title: [The effect of neurotropic agents on lipid peroxidation in the heart and stomach with neurogenic lesions].
    Author: Bul'on VV, Zavodskaia IS, Khnychenko LK.
    Journal: Eksp Klin Farmakol; 1994; 57(3):18-20. PubMed ID: 8049619.
    Abstract:
    Neurogenic gastric lesions in rats were induced by a combination of immobilization and 3-hour electrostimulation. Neurogenic cardiac injury in rabbits were induced by 3-hour electrical stimulation of the aortic arch. Thereafter the activation of lipid peroxidation in the stomach and heart was recorded. There was an increase in MDA levels and a decrease in antioxidative enzyme activity in the tissues and serum (catalase and superoxide dismutase). The administration of the neurotropic drugs which restore the activity of the sympathetic nervous system (L-DOPA, aethimizol, fenibut and piracetam) was shown to normalize the processes of lipid peroxidation.
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