These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of isothiocyanate alkyl chain-length on hamster liver cytochrome P-450 activity.
    Author: Hamilton SM, Zhang Z, Teel RW.
    Journal: Cancer Lett; 1994 Jul 29; 82(2):217-24. PubMed ID: 8050094.
    Abstract:
    The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is metabolized by various isozymes of cytochrome P-450 present in microsomes. In this study, we examined the effects of the isothiocyanate homologues, phenyl isothiocyanate (PITC), benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC) and phenylpropyl isothiocyanate (PPITC) on the mutagenicity and in vitro metabolism of NNK by Syrian golden hamster liver microsomes and on the in vitro microsomal metabolism of testosterone. Each isothiocyanate compound inhibited N-oxidation and alpha-hydroxylation reactions of NNK that, except for PITC, correlated with an inhibition of microsomal-mediated mutagenicity of NNK in Salmonella typhimurium TA1535. Each isothiocyanate also inhibited cytochrome P-450-mediated hydroxylation reactions of the metabolism of testosterone. In general, the inhibitory potency of the isothiocyanates corresponded with the length of the alkyl chain of the compound. Our data support the ability of isothiocyanates to inhibit the activity of a number of isozymes of cytochrome P-450.
    [Abstract] [Full Text] [Related] [New Search]