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  • Title: [Pharmacokinetics of paracetamol after removal of ovaries in rabbits].
    Author: Kwiatkowski A, Gawrońska-Szklarz B, Droździk M, Wójcicki J.
    Journal: Endokrynol Pol; 1993; 44(1):73-9. PubMed ID: 8050393.
    Abstract:
    The study was aimed at the determination of the effect of estrogens on paracetamol pharmacokinetics in female rabbits subjected to bilateral ovariectomy. Eighteen female rabbits divided into two groups, control and experimental, subjected to ovariectomy, were used in the study. Pharmacokinetic experiments were carried out in all the animals before the operation, 1 month after, and 2 months after ovariectomy. Samples of blood were taken periodically during 24 hours after intragastric administration of paracetamol at a dose of 50 mg/kg of body weight. An open two-compartment model was used for the description of concentration changes. A decrease in the area under the curve of changes of paracetamol concentration and in the half-time of the elimination phase, as well as an increase in the total clearance of the drug, have been observed. The results of the study indicate that the rate of elimination of paracetamol is higher in ovariectomized animals.
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