These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Flow cytometry detected S-phase fraction and ploidy as prognostic parameters in primary, node-negative breast cancer].
    Author: Winter K, Eidtmann H, Jonat W.
    Journal: Geburtshilfe Frauenheilkd; 1994 May; 54(5):291-4. PubMed ID: 8050690.
    Abstract:
    100 specimens of patients with primary node-negative breast cancer were examined by flow cytometry. 64 tumours were shown to be diploid and 36 tumours were aneuploid. The median was the cut-off level for tumours with low S-phase (< or = 10.9%) and high S-phase values (> 10.9%). Aneuploid tumours were associated with high S-phase fraction. The average length of follow-up was 42 months. In univariate analysis for disease-free survival, diploid tumours were shown to have a slightly better prognosis than aneuploid tumours (p = 0.07). This trend could not be shown in multivariate analysis. The S-phase fraction proved to be an independent prognostic factor. Patients, whose tumours had S-phase fractions < or = 10.9%, had significantly longer disease-free survival in univariate (long-rank-test: p = 0.021), as well as in multivariate analysis according to the Cox regression model (p = 0.033). Since, as already stated, the S-phase fraction is an independent prognostic factor for node-negative breast cancer, further adjuvant therapy studies should take this factor into consideration.
    [Abstract] [Full Text] [Related] [New Search]