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  • Title: An autoradiographic study of the renewal of mouse bronchiolar epithelium following bromobenzene exposure.
    Author: Ogawa T, Tsubakihara M, Ichikawa M, Kanisawa M.
    Journal: Toxicol Pathol; 1993; 21(6):547-53. PubMed ID: 8052801.
    Abstract:
    This study discusses mice bronchiolar epithelium following bromobenzene (BrBZ) exposure. Our study shows 3 cell types following BrBZ exposure: Clara cells, ciliated cells, and newly discovered BrBZ-resistant nonciliated cells. Through electron microscopic autoradiography, we were able to show the proliferative ability of BrBZ-resistant nonciliated cells. This finding suggests that BrBZ-resistant nonciliated cells may function as progenitor cells. In addition to discovering this new cell type, our results also demonstrate and confirm the proliferative ability of modified Clara cells.
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