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  • Title: Treatment of stage III non-small cell lung cancer with thoracic radiation therapy and simultaneous platinum chemotherapy.
    Author: Bonomi P.
    Journal: Semin Oncol; 1994 Jun; 21(3 Suppl 6):101-8. PubMed ID: 8052869.
    Abstract:
    Preclinical trials have shown platinum compounds to enhance radiation, and clinical trials that tested simultaneous cisplatin and radiation in a variety of tumors have demonstrated acceptable toxicity. Subsequent reports described the use of platinum chemotherapy and concurrent thoracic radiation therapy for the treatment of locally advanced non-small cell lung cancer. In patients whose disease was considered unresectable, investigators have tested cisplatin primarily as a single agent. Phase III trials compared single-agent cisplatin and simultaneous radiation with radiation alone. Selected phase II trials studied cisplatin, or carboplatin and radiation. Two phase II trials evaluated cisplatin-containing combination chemotherapy and simultaneous split-course radiation therapy in nonsurgical patients. In contrast to nonsurgical trials, studies of preoperative treatment have tested cisplatin-containing combination chemotherapy regimens and simultaneous radiation. Of particular interest are the implications of these studies for future phase III trials.
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