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  • Title: [Stimulation of oxygen metabolism in human blood phagocytes as affected by tuftsin-like peptides derived from the C-reactive protein molecule].
    Author: Polevshchikov AV, Nazarov PG.
    Journal: Biull Eksp Biol Med; 1993 Jan; 115(1):55-6. PubMed ID: 8054580.
    Abstract:
    Effects of synthetic peptides analogous to those cleaved by proteolysis from human C-reactive protein (CRP) molecule on the level of oxygen metabolism of blood neutrophils and monocytes were studied. The effects of the peptides were compared with the effect of tetrapeptide Thr-Lys-Pro-Arg (tuftsin). CRP-derived peptides stimulated phagocyte oxygen metabolism as effectively as tuftsin. Their effect did not depend on the presence of a second stimulus (E. Coli LPS) in the medium. Neutrophils and monocytes responded to CRP-derived peptides differently.
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