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  • Title: Splenic hypofunction in systemic lupus erythematosus.
    Author: Childs JC, Adelizzi RA, Dabrow MB, Freed N.
    Journal: J Am Osteopath Assoc; 1994 May; 94(5):414-5. PubMed ID: 8056631.
    Abstract:
    Systemic lupus erythematosus is a relatively common autoimmune disease in the United States. Hyposplenism is infrequently described in patients with systemic lupus erythematosus. It is seen in up to 5% of patients and is thought to be caused by vasculitic changes within the spleen. The diagnosis of hyposplenism can be made easily by identifying Howell-Jolly bodies on a peripheral blood smear. The authors describe a patient with systemic lupus erythematosus associated with hyposplenism and discuss possible diagnostic and treatment implications.
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