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  • Title: [HLA class I and II antigens and diffuse toxic goiter].
    Author: Kalinin AP, Kamynina TS, Zaretskaia IuM, Abramov VIu, Klinova EG, Karachintsev VI.
    Journal: Ter Arkh; 1993; 65(3):81-5. PubMed ID: 8059394.
    Abstract:
    The incidence rate of HLA class I and II antigens has been studied in 168 and 82 patients with diffuse toxic goiter, respectively. Positive association is found for HLA antigens A2, A3, A28, B8, B15, B17, Cw4, DR5; negative one with antigens A24, Bw4, Bw6, Cw1, Cw2, Cw3, Cw5, DR9. Prevalence of antigens B15, B17, Cw4, DR5 is associated with thyrotoxicosis severity, A2 with recurrent toxic goiter. Antigen B8 plays the role of an immunogenetic marker of endocrine ophthalmopathy.
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