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  • Title: Direct fetal administration of immunoglobulins: another disappointing therapy in alloimmune thrombocytopenia.
    Author: Weiner E, Zosmer N, Bajoria R, Sepulveda W, Vaughan JI, Letsky EA, Fisk NM.
    Journal: Fetal Diagn Ther; 1994; 9(3):159-64. PubMed ID: 8060511.
    Abstract:
    Current management strategies to prevent fetal intracranial haemorrhage in perinatal alloimmune thrombocytopenia (PAIT) include serial platelet transfusion and/or maternal high-dose intravenous immunoglobulin (IVIG) administration. The former involves multiple invasive procedures, while the latter is both expensive and of questionable efficacy. We report the use of direct fetal IVIG in 2 fetuses with PAIT, undergoing serial intrauterine platelet transfusions. Fetal IVIG had no effect on fetal platelet count. We conclude that direct fetal IVIG administration does not appear to have a role in the management of PAIT, and that current management strategies remain far from ideal.
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