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  • Title: Neurotrophins affect survival and neuritogenesis by adult injured auditory neurons in vitro.
    Author: Lefebvre PP, Malgrange B, Staecker H, Moghadass M, Van de Water TR, Moonen G.
    Journal: Neuroreport; 1994 Apr 14; 5(8):865-8. PubMed ID: 8061284.
    Abstract:
    This study evaluates the trophic effects of three neurotrophins on traumatized adult auditory neurons in culture, and the presence of these neurotrophins in cochlear nucleus tissue. BDNF and NT-3 promoted survival but very limited neuritogenesis by adult auditory neurons in vitro, while NGF, although without a survival effect, evoked a robust neuritic outgrowth response when combined with BDNF. Messenger RNAs that encode for NGF, BDNF and NT-3 were detected by RT-PCR in RNA extracts from adult cochlear nuclei tissue. Based on these in vitro and in vivo findings, we propose NT-3 as the agent of the peripheral target-derived survival promoting effect and NGF, BDNF, and NT-3 as mediators of trophic influences originating from the central target (i.e. cochlear nucleus).
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