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  • Title: Blockers of Ca2+ channels in the plasmalemma of perfused Characeae cells.
    Author: Zherelova OM, Grishchenko VM, Chaylakhyan LM.
    Journal: Comp Biochem Physiol Pharmacol Toxicol Endocrinol; 1994 Mar; 107(3):475-80. PubMed ID: 8061954.
    Abstract:
    Ionic currents in the plasmalemma of perfused Nitella syncarpa cells identified as currents through Ca2+ channels were registered for the first time. The effect of 1,4-dihydropyridine derivatives (nifedipine, nitrendipine, riodipine) and phenylalkylamines (verapamil, D600) as well as the agonist CGP-28392 on the Ca2+ channels in the plasmalemma of perfused cells of Nitellopsis obtusa and Nitella syncarpa have been studied. A blocking effect of 1,4-dihydropyridine derivatives and phenylalkylamines on the plasmalemma Ca2+ channels has been detected. Phenylalkylamines have been found to block both inward and outward Ca2+ currents. The activating effect of the agonist CGP-28392 on the Ca2+ channels of plasmalemma has been shown.
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