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  • Title: Hemispheric disconnection in Marchiafava-Bignami disease: clinical, neuropsychological and MRI findings.
    Author: Berek K, Wagner M, Chemelli AP, Aichner F, Benke T.
    Journal: J Neurol Sci; 1994 May; 123(1-2):2-5. PubMed ID: 8064315.
    Abstract:
    We report a single-case study of a patient suffering from Marchiafava-Bignami disease (MBD), a rarely intra vitam diagnosed syndrome with focal demyelination in the corpus callosum, which is usually found in patients with chronic alcohol abuse. Our study explored a variety of motor, sensory and visual functions. Striking features were left apraxia caused by two lesions in the rostral area, and left hemidyslexia related to a large splenial lesion demonstrated by MRI. As symptoms of disconnection may remain undetected clinically, MRI is a most useful tool for the diagnosis of MBD.
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