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  • Title: The prophylactic use of thio-tepa and urokinase in transitional cell carcinoma of the bladder: a preliminary report.
    Author: Hisazumi H, Uchibayashi T, Naito K, Misaki T, Miyazaki K.
    Journal: J Urol; 1975 Sep; 114(3):394-8. PubMed ID: 806708.
    Abstract:
    The prevention of recurrences of bladder cancer was attemped in 48 patients by means of the combined intravesical instillation of thio-tepa and urokinase and in 28 patients through the instillation of thio-tepa alone. The recurrence rates of both therapies for the postoperative 18 months were 7.9 and 32.6 per cent, respectively, indicating a significant drop in the recurrence rate in the group subjected to the combined therapy. No significant difference was found between the 2 instillation groups in terms of the blood transmission of 32-P thio-tepa. Serious leukopenia was found in 2 of the 48 patients receiving the combined instillation therapy but we concluded that this was not attributable to the use of urokinase.
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