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  • Title: [An immunoenzyme method for determining IgA antibodies to lipopolysaccharide in secretions in the diagnosis of shigellosis].
    Author: Salamatova SA, Sukhoroslova LI, Shalamberidze IA, Brusenina ND.
    Journal: Zh Mikrobiol Epidemiol Immunobiol; 1993; (3):85-9. PubMed ID: 8067099.
    Abstract:
    IgA antibodies to S. sonnei and S. flexneri lipopolysaccharides (LPS) in secretions, as well as Escherichia coli LPS in coprofiltrates of children with acute diarrhea, were determined with the use of enzyme immunoassay (EIA). In adult patients with dysentery serum and salivary anti-LPS antibodies were assayed. The results of EIA showed that children aged up to 18 months had an elevated level of LPS of the causative agent in their coprofiltrates. The specificity of this assay permitted its use for finding out the agent of acute enteric infection. In adults, the levels of salivary anti-LPS antibodies in dysentery patients and in healthy persons significantly differed, which might also be regarded as a sign of Shigella infection. No significant difference in the levels of IgG antibodies to LPS in the saliva of sick and healthy persons was registered. IgA antibodies were found to be active mainly against common determinants of S. sonnei and S. flexneri LPS and thus not suitable for the differentiation of the causative agents of dysentery. For this purpose, the levels of serum IgG antibodies to LPS of different Shigella species should be determined.
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