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  • Title: The effect of short-term alloxan-induced diabetes on the activity of drug metabolizing enzymes.
    Author: Pachecka J, Kobylińska K, Suchocka Z, Kuczyńska J.
    Journal: Acta Pol Pharm; 1993; 50(6):435-9. PubMed ID: 8067257.
    Abstract:
    Chemical diabetes produced in male rats by treatment with alloxan (45 mg/kg) decreased aminopyrine N-demethylase activity but not hepatic microsomal protein, cytochrome P-450 and cytochrome b5 contents. In contrast, diabetes increased aniline hydroxylase activity. Glutathione S-transferase activity and the most of the forms of UDP-glucuronyltransferase were decreased but phenolsulphotransferase activity was not affected in alloxan-induced rats. These results suggest that observed changes may led to alteration of drug metabolism and toxicity in diabetes.
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