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  • Title: High dietary fat, elevation of rat serum prolactin and mammary cancer.
    Author: Chan PC, Didato F, Cohen LA.
    Journal: Proc Soc Exp Biol Med; 1975 May; 149(1):133-5. PubMed ID: 806916.
    Abstract:
    We investigated the concept that the enhanced development of DMBA-induced mammary adenocarcinomas in rats fed a high fat diet might be mediated by prolactin via the hypothalamic-pituitary system rather than by a direct effect of a fat on the mammary gland itself. Prolactin levels in serum from female Sprague-Dawley rats fed high (20%) and low (0.5%) lard diets for 2 and 5 mo were measured by radioimmunoassay. The levels in rats at proestrus-estrus on high-lard diets were significantly higher (250 ng/ml) than those on a low lard diet (100 ng/ml). At metestrus-diestrus prolactin levels were approximately 50 ng/ml regardless of diet. Thus, the tumor-enhancing effect of a high fat diet may be indirect and mediated by neuro-hormonal changes in the hypothalamic centers controlling prolactin synthesis and secretion.
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