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Title: Ethylene oxide sterilization: III--Influence of carrier nature in a biological monitor performance. Author: Pinto TJ, Saito T, Iossif M. Journal: J Pharm Sci Technol; 1994; 48(3):155-8. PubMed ID: 8069517. Abstract: The ethylene oxide sterilization process control should take into account several parameters, so that only the biological monitor can integrate in all of them, presenting a biological challenge similar to the product under sterilization conditions. The authors evaluated spore resistance on several different carriers: paper, aluminum foil and plastic. The influence was studied through the challenge of sub-lethal cycles, followed by the lethality study and the D-value calculation. There was a significant statistical difference in spore resistance between paper and plastic carriers.[Abstract] [Full Text] [Related] [New Search]