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  • Title: Bcl-2 inhibits T-cell-mediated cytolysis of a leukemia cell line.
    Author: Torigoe T, Millan JA, Takayama S, Taichman R, Miyashita T, Reed JC.
    Journal: Cancer Res; 1994 Sep 15; 54(18):4851-4. PubMed ID: 8069851.
    Abstract:
    The bcl-2 gene becomes dysregulated in its expression in a wide variety of human cancers and has been shown to block both spontaneous and drug-induced cell death, thus conferring a selective survival advantage on malignant cells. The biochemical mechanism by which bcl-2 promotes cell survival remains enigmatic but appears to involve a downstream event in an evolutionarily conserved cell death pathway. Here we report that gene transfer-mediated increases in Bcl-2 protein levels in the human leukemia line Jurkat render these cells more resistant to induction of DNA fragmentation and cytolysis by a cloned T-cell. The killing mechanism used by these particular T-cells was consistent with apoptosis, as opposed to necrosis, in that DNA degradation occurred as a prelysis event. The findings raise the possibility that dysregulation of bcl-2 gene expression could play a role in the avoidance of immune surveillance mechanisms by cancer cells.
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