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  • Title: Effects of intracervical injection of hyaluronidase in primigravidae during labour.
    Author: Gupta T, Verma NK, Sood A.
    Journal: J Indian Med Assoc; 1994 Feb; 92(2):47-8. PubMed ID: 8071553.
    Abstract:
    A study was conducted on 75 primigravidae in labour of which 50 were injected with intracervical injection of hyaluronidase and 25 were taken as control. Labour could be accelerated and shortened by an average of 1.95 hours (p < .01) after intracervical injection of hyaluronidase. Its effect was insignificant on the latent phase of labour while it significantly shortened the active phase of labour by 2.09 hours (p < .001). Its effect on maximum rate of cervical dilatation (0.85 cm/hour) was also found to be statistically significant ie, p < .001. Hyaluronidase had no effect on uterine contractions, duration of 2nd and 3rd stages of labour and on involution of the uterus. There was no incidence of cervical tear in any of the cases.
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