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  • Title: High rate of oxacillin-resistant Staphylococcus aureus isolates in an Italian University Hospital.
    Author: Venditti M, Baiocchi P, Brandimarte C, Capone A, Fimiani C, Santini C, Tarasi A.
    Journal: J Chemother; 1994 Feb; 6(1):25-8. PubMed ID: 8071673.
    Abstract:
    We reviewed our routine clinical laboratory records from January 1990 to March 1993 to evaluate the rate of oxacillin-resistance among nosocomial isolates of Staphylococcus aureus. Of 265 clinically significant isolates, 174 (65%) were oxacillin-resistant S. aureus (ORSA). Most of these strains were obtained from surgery patients and/or were isolated from surgical wounds. The isolations of S. aureus increased during the study period: 45 in 1990, 50 in 1991, 130 in 1992 and 40 in the first trimester of 1993. The annual rates of ORSA among S. aureus isolated varied from 62 to 68% through these years. Most ORSA isolates proved resistant to ciprofloxacin, gentamicin and rifampicin, and susceptible to vancomycin, netilmicin and cotrimoxazole. Based on these results, the need for a stringent application of infection control measures is outlined.
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