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  • Title: Effects of combinations of a molsidomin with different antithrombotic drugs in laser-induced thrombosis.
    Author: Giedrojć J, Bielawiec M, Jaromin J, Breddin HK.
    Journal: Mater Med Pol; 1993; 25(3-4):153-7. PubMed ID: 8072321.
    Abstract:
    Molsidomin is a vasodilating drug and a specific activator of the endothelium-derived relaxing factor (EDRF). Molsidomin has been found to prevent thrombus formation in various animal thrombosis models. To obtain more information about a possible interaction of Molsidomin with other vasoactive agents, Molsidomin, Iloprost, HN-11500, Fraxiparin and Aspisol have been investigated alone and in combinations. The antithrombotic effect of these agents was studied in a thrombosis model in rats, in which mesenteric venules, with a diameter of 20-30 microns, were injured by Argon laser produced lesions. In this animal microcirculatory thrombosis model all agents showed a significant dose dependent antithrombotic effect. A strong additive effect was observed when Molsidomin was infused together with Iloprost. An additive effect was also observed when Molsidomin was administered with Fraxiparin. There was a slight but non significant effect between Molsidomin and the thromboxane receptor antagonist. No additive effect was shown when a minimal effective dose of Molsidomin was infused together with a minimal effective dose of Aspisol.
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